The impact of intrarenal nitric oxide synthase inhibition on renal blood flow and function in mild and severe hyperdynamic sepsis

Abstract

Objective: In experimental hyperdynamic sepsis, renal function deteriorates despite renal vasodilatation and increased renal blood flow. Because nitric oxide is increased in sepsis and participates in renal blood flow control, we investigated the effects of intrarenal Nω-nitro-l-arginine methyl ester, a nonspecific nitric oxide synthase inhibitor, in mild and severe sepsis. Design: Prospective crossover and randomized control interventional studies. Setting: University-affiliated research institute. Subjects: Thirty-two merino ewes. Intervention: Examination of responses to intrarenal infusion of Nω-nitro-l-arginine methyl ester for 8 hrs in unilaterally nephrectomized normal sheep and in sh..